Publicación

Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women

  • BRITISH JOURNAL OF NUTRITION
  • Autores
    Ruiz, JR; Larrarte, E; Margareto, J; Ares, R; Alkorta, P; Labayen, I
  • Año Publicación
    2011
  • Volumen
    106
  • Número
    4
  • Pág. Inicio
    486
  • Pág. Fin
    490
  • Pág. Fin
    486
Referencia Citadas
21
Citas Web of Science
15
Total de veces citado (Z9)
16
Recuento Uso 180 días
1
Recuento Uso 5 años
3

The aim of the present study was to investigate the association of PLIN1 114820 > A (rs894160) and PLIN1 13041A > G (rs2304795) polymorphisms with body composition, energy and substrate metabolism, and the metabolic response to a 12-week energy-restricted diet in obese women. The study comprised a total of seventy-eight obese (BMI 34.0 (SD 2.8) kg/m(2)) women (age 36.7 (SD 7) years). We measured weight, height and waist circumference before and after a 12-week controlled energy-restricted diet intervention. Body fat mass and lean mass were measured by dual-energy X-ray absorptiometry. RMR and lipid oxidation rate were measured by indirect calorimetry. We also analysed fasting plasma glucose, insulin, cholesterol and leptin. Women carrying the 11482A allele had a lower reduction in waist circumference than non-A allele carriers (3.2 (SD 0.5) v. 4.6 (SD 0.6)%, respectively, P=0.047; P for gene-diet interaction=0.064). Moreover, women with the 11482A allele had a higher decrease in lipid oxidation rate than non-A allele carriers (58.9 (SD 6.7) v. 31.3 (SD 8.2)%, respectively, P=0.012; P for gene-diet interaction= 0004). There was no interaction effect between the 13041A > G polymorphism and diet-induced changes on the outcome variables (all P > 0.1). These results confirm and extend previous findings suggesting that the PLIN1 114820 > A polymorphism plays a modulating role on diet-induced changes in body fat and energy metabolism in obese women.


Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UG

Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UGR