Publicación

Maternal PPARG Pro12Ala polymorphism is associated with infant’s neurodevelopmental outcomes at 18 months of age

  • EARLY HUMAN DEVELOPMENT
  • Autores
    Torres-Espinola, FJ; Altmae, S; Segura, MT; Jerez, A; Anjos, T; Chisaguano, M; Lopez-Sabater, MC; Entrala, C; Alvarez, JC; Agil, A; Florido, J; Catena, A; Perez-Garcia, M; Campoy, C
  • Año Publicación
    2015
  • Volumen
    91
  • Número
    8
  • Pág. Inicio
    457
  • Pág. Fin
    462
  • Pág. Fin
    457
Referencia Citadas
38
Citas Web of Science
3
Total de veces citado (Z9)
3
Recuento Uso 5 años
14

Background: Peroxisome proliferator activated receptors (PPARs) are ligand activated transcription factors with crucial functions in lipid homeostasis, glucose metabolism, anti-inflammatory processes, placental development, and are involved in cognitive functions and neurodegenerative diseases. Polymorphisms in PPAR genes are shown to influence the activity of these receptors. Aims: 1) To examine the association of PPARG Pro12Ala polymorphism in pregnant women and their offspring on infant’s neurodevelopmental outcomes during the first 18 months of life; 2) to determine the influence of Pro12Ala polymorphism on fatty acid concentrations in plasma phospholipids and placental tissue. Study design: 138 mother-infant pairs from the PREOBE observational study were genotyped for PPARG Pro12Ala. Plasma phospholipids and placental fatty acid concentrations were measured at delivery. Infants’ neuropsychological assessment at 6 and 18 months of age was performed using Bayley III. Results: The effect of Pro12Ala on infant’s neurodevelopmental outcomes was detected at 18 months, but not at 6 months of age. 18 months old infants born to mothers with wild-type Pro12 genotype had better cognitive (OR = 5.11, 95% CI: 1.379-18.96, p = 0.015), language (OR = 3.41, 95% CI: 1.35-11.24, p = 0.044), and motor development scores (OR = 4.77, 95% CI: 1.243-18.33, p = 0.023) than the Ala allele carriers. Pro12Ala variants did not seem to affect fatty acids concentrations in blood nor in placenta at delivery. Conclusions: Infants born to mothers with Pro12 genotype have better neurodevelopmental outcomes at 18 months of age than Ala allele carriers, indicating a long-term transplacental action of PPAR gamma variants on foetal brain development. (C) 2015 Elsevier Ireland Ltd. All rights reserved.


Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UG

Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UGR