Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness

OBJECTIVES: To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity. METHODS: Plasma interleukin-1 beta (IL-1 beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8-11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry. RESULTS: IL-6 (beta=-0.136) and VEGF (beta=-0.099) were associated with TBLH BMC, while TNF-alpha (beta=-0.345) and IL-1 beta (beta = 0.212) were associated with LS BMC (P < 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P= 0.122) and TNF-alpha with LS BMC (P=0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (beta=-0.152) and TNF-alpha with LS BMC (beta=-0.491) in the low-fitness group, while no association was found in the highfitness group. CONCLUSION: IL-6, VEGF, TNF-alpha, and IL-1 beta are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-alpha on bone mass.

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *