Publicación

Evidence of high F-18-fluorodeoxyglucose uptake in the subcutaneous adipose tissue of the dorsocervical area in young adults

  • EXPERIMENTAL PHYSIOLOGY
  • Autores
    Martinez-Tellez, B; Sanchez-Delgado, G; Alcantara, JMA; Acosta, FM; Amaro-Gahete, FJ; Osuna-Prieto, FJ; Perez-Bey, A; Jimenez-Pavon, D; Llamas-Elvira, JM; Gil, A; Aguilera, CM; Rensen, PCN; Ruiz, JR
  • Año Publicación
    2019
  • Volumen
    104
  • Número
    2
  • Pág. Inicio
    168
  • Pág. Fin
    173
  • Pág. Fin
    168
Referencia Citadas
20

Neonates have subcutaneous brown adipose tissue (BAT) in the dorsocervical area, and it is thought that these depots gradually disappear with age. Here, we determined that young adults have high F-18-flurodeoxyglucose (F-18-FDG) uptake in the subcutaneous adipose tissue (SAT) of the dorsocervical area. A total of 133 young adults (age 22 +/- 2 years; body mass index 25 +/- 5 kg m(2)) were included in the study. We performed a shivering threshold test for every participant. Later, we performed 2 h of personalized cold exposure, immediately before a positron emission tomography/computed tomography scan. We showed that 23 of 133 participants had F-18-FDG uptake in the dorsocervical area that achieved the criteria to be considered BAT, mainly in women (96%, n = 22 of 23). In the whole sample, the glucose uptake in the SAT of the dorsocervical area was positively correlated with BAT volume and activity located in the supraclavicular area. We showed that the F-18-FDG uptake of the SAT of the dorsocervical area in humans is different from that of other SAT areas. Future studies are warranted to confirm the brown signature of this tissue.


Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UG

Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UGR