PUBMEP study is a longitudinal analysis using data from 96 boys and girls undergoing sexual maturation. Children were allocated into five experimental groups according to their obesity and insulin resistance (IR) status before and after the onset of puberty.
Pubertal stage was evaluated by clinicians in all participants according to the Tanner scale (I for prepubertal and II-V for pubertal children). All details regarding the adopted longitudinal design are illustrated in Figure . Obesity status was defined according to BMI by using the age- and sex-specific cut-off points. The IR status was defined by means of the homeostatic model assessment for insulin resistance (HOMA-IR) index.
The objective of the project is to determine biomarkers and epigenetic marks associated with the development of metabolic complications during the development of puberty according to the state of health in the prepuber age.
Scientific papers:
- Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty. Anguita-Ruiz A, González-Gil EM, Rupérez AI, Llorente-Cantarero FJ, Pastor-Villaescusa B, Alcalá-Fdez J, Moreno LA, Gil Á, Gil-Campos M, Bueno G, Leis R, Aguilera CM. J Clin Med. 2020 Jun 2;9(6):E1705. doi: 10.3390/jcm9061705.
- The protein S100A4 as a novel marker of insulin resistance in prepubertal and pubertal children with obesity. Anguita-Ruiz A, Mendez-Gutierrez A, Ruperez AI, Leis R, Bueno G, Gil-Campos M, Tofe I, Gomez-Llorente C, Moreno LA, Gil Á, Aguilera CM. Metabolism. 2020 Apr;105:154187. doi: 10.1016/j.metabol.2020.154187. Epub 2020 Feb 18.
