Cost-effectiveness of a physical exercise program in perimenopausal women

Regional Ministry for Health of Andalusia.
  • Importe
    38.500 €
  • 2014
  • – 2015
flamenco project

Spain is the second country in the world that consumes the most drugs. The average pharmaceutical cost per inhabitant in 2011 in Andalusia was € 219.2. Said pharmaceutical expense increases during the perimenopausal period. According to the Study of the economic impact of sport practice on health spending by the Health Department of the Generalitat de Catalunya, for every euro invested in sport promotion, there is a saving of 50 euros in health spending accumulated over 15 years.


  1. To analyze the effect (cost-effectiveness) of a physical exercise program on the pharmaceutical prescription of a sample of Andalusian women aged between 45-60 years.
  2. To study the level of physical activity and sedentary lifestyle (objectively measured by accelerometry), the functional capacity, quality of life and clinical profile of said population.
  3. To analyze the relationship between levels of physical activity / sedentary lifestyle and pharmaceutical spending. In the present project, a concurrent physical exercise program was carried out aimed at minimizing the symptoms and health problems associated with the perimenopausal period: dyslipidemia, diabetes, anxiety, depression, quality of life, quality of sleep, obesity, osteoporosis, and cardiovascular diseases. A total of 160 perimenopausal women were randomly assigned to the physical exercise intervention group (n = 80) or the usual care group (n = 80). Participants in the intervention group trained 3 days / week (60 min per session) for 16 weeks.

We trust that the results will shed light on the implementation of health promotion programs that are both beneficial to Andalusian public health and to the family, institutional and community economy. Identifier: NCT02358109


Data analysis and publication preparation. 


Regional Ministry of Health and Social Welfare of the Junta de Andalucía (grants for the financing of biomedical and health science research in Andalusia). PI-0667-2013


See also in The National Center for Biotechnology Information

  1. Coll-Risco I, Acosta-Manzano P, Borges-Cosic M, Camiletti-Moiron D, Aranda P, Soriano-Maldonado A, Aparicio VA. Body Composition Changes Following a Concurrent Exercise Intervention in Perimenopausal Women: The FLAMENCO Project Randomized Controlled Trial. J Clin Med. 2019 Oct 14;8(10). pii: E1678. doi: 10.3390/jcm8101678. PMID: 31615008
  2. Nuria Marín-Jiménez, Pedro Jesús Ruiz-Montero, Marta De la Flor-Alemany, Pilar Aranda, Virginia A. Aparicio, Association of objectively-measured sedentary behaviour and physical activity levels with health-related quality of life in perimenopausal women. The FLAMENCO project. Menopause. In press.
  3. M. Flor-Alemany, N. Marín-Jiménez, T. Nestares, M. Borges-Cosic, P. Aranda, V.A. Aparicio. Mediterranean diet and body composition during perimenopause. The FLAMENCO Project. Maturitas. In press
  4. Aparicio VA, Marín-Jiménez N, Coll-Risco I, de la Flor-Alemany M, Baena-García L, Acosta-Manzano P, Aranda P. Doctor, ask your perimenopausal patient about her physical fitness; association of self-reported physical fitness with cardiometabolic and mental health in perimenopausal women: the FLAMENCO project. Menopause. 2019 Oct;26(10):1146-1153. doi: 10.1097/GME.0000000000001384. PMID: 31513090
  5. Acosta-Manzano P, Segura-Jiménez V, Coll-Risco I, Borges-Cosic M, Castro-Piñero J, Delgado-Fernández M, Aparicio VA. Association of sedentary time and physical fitness with ideal cardiovascular health in perimenopausal women: The FLAMENCO project. Maturitas. 2019 Feb;120:53-60. doi: 10.1016/j.maturitas.2018.11.015. Epub 2018 Nov 23. PMID:30583765
  6. Coll-Risco I, Borges-Cosic M, Acosta-Manzano P, Camiletti-Moirón D, Aranda P, Aparicio VA. Effects of concurrent exercise on cardiometabolic status during perimenopause: the FLAMENCO Project. Climacteric. 2018 Dec;21(6):559-565. doi: 10.1080/13697137.2018.1526892. Epub 2018 Nov 5. PMID: 30392388
  7. Špacírová Z, Epstein D, García-Mochón L, Aparicio VA, Borges-Cosic M, López Del Amo MP, Martín-Martín JJ. Cost-effectiveness of a primary care-based exercise intervention in perimenopausal women. The FLAMENCO Project. Gac Sanit. 2018 Oct 16. pii: S0213-9111(18)30177-8. doi: 10.1016/j.gaceta.2018.05.012. PMID: 30340794
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  9. Ruiz-Cabello P, Coll-Risco I, Acosta-Manzano P, Borges-Cosic M, Gallo-Vallejo FJ, Aranda P, López-Jurado M, Aparicio VA. Influence of the degree of adherence to the Mediterranean diet on the cardiometabolic risk in peri and menopausal women. The Flamenco project. Nutr Metab Cardiovasc Dis. 2017 Mar;27(3):217-224. doi: 10.1016/j.numecd.2016.10.008. Epub 2016 Nov 20. PMID: 28003111
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  11. Carbonell-Baeza A, Soriano-Maldonado A, Gallo FJ, López del Amo MP, Ruiz-Cabello P, Andrade A, Borges-Cosic M, Peces-Rama AR, Spacírová Z, Álvarez-Gallardo IC, García-Mochón L, Segura-Jiménez V, Estévez-López F, Camiletti-Moirón D, Martín-Martín JJ, Aranda P, Delgado-Fernández M, Aparicio VA. Cost-effectiveness of an exercise intervention program in perimenopausal women: the Fitness League Against MENopause COst (FLAMENCO) randomized controlled trial. BMC Public Health. 2015 Jun 17;15:555. doi: 10.1186/s12889-015-1868-1. PMID: 26081934

Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UG

Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UGR