Signe Altmäe

Signe Altmäe

  Guarantor Researcher
Research Guarantors
  • Department
    Department of Biochemistry and Molecular Biology I
  • Academic title
    Researcher Ramón y Cajal
  • Research group
  • Universidad de Granada

In 2010 I obtained my Doctoral Degree in Gene Technology at the University of Tartu (Estonia), which followed by a 20-months Post-Doctoral period at Karolinska Institutet (Sweden). In 2011 I was awarded with a competitive Spanish Ministry grant ‘Estancias de jóvenes doctores extranjeros en centros Españoles’ and in 2013 I obtained the highly prestigious Marie Curie Post-Doctoral Individual Fellowship for performing Post-Doctoral research at the University of Granada (Spain). In 2016 I was elected as Marie Curie Senior Researcher at the Department of Women’s and Children’s Health, Karolinska Institutet, Sweden and in 2018 I obtained the prestigious Ramon y Cajal Researcher position in a Spanish University.

To summarise, my biggest achievements and contributions to date are:

• 60 scientific publication, where 3 are published in the top high-impact journals Human Reproduction Update (IF 12.9) and Nature Reviews Urology (IF 9.3).

• Gathering, coordinating and leading a network of top scientists from all around the World in the reproductive medicine field (Europe, USA, Australia, including Stanford, UCSF, Southampton, Utrecht, Leuven Universities) that resulted in GUIDELINES for the design, analysis and interpretation of ‘omics’ data in Human Reproduction (Altmäe et al. 2014 Hum Reprod Update, IF 12.9).

• Highly prestigious and competitive grants Marie Curie Post-Doctoral grant and Ramon y Cajal fellowship.

• Invited speaker to 30 international conferences and workshops.

• Elected as Junior Deputy in ESHRE Special Interest Group of Reproductive Genetics. ESHRE, European Society of Human Reproduction and Embryology is the World-leading society of over 8000 members and is organising advanced training courses and conferences and meetings, and communicates research results to lay public (2015-2017).

• Elected as Deputy in ESHRE Special Interest Group of Reproductive Genetics (2019-ongoing).

• Elected member of the SEF (Sociedad Espanola de Fertilidad) Special Interest Group of Genética Reproductiva.

• Elected expert of the ESHRE Endometriosis Guideline group that will provide guidelines in 2020 of identifying and treating endometriosis for the doctors around the world.

• Invited as main speaker at ESHRE Annual Meeting in 2015 (around 10 000 participants), and session chair and posters chair at ESHRE Annual Meetings (2016, 2017, 2018).

• Section Editor in Reproductive BioMedicine Journal that belongs to the Quartile 1 in the field.

• Associate Editor in Frontiers in Endocrinology, Reproduction section.

• Expert reviewer in international grants.

• PI of one international grant (FP7 Marie Curie) and PI of three national grants (MINECO-FEDER), Work Package leader in international and national grants (FP7 SARM project, Estonian IUT34-16 project, MINECO DEP2016-79512R).

• Elected as Marie Curie Senior Researcher in FP7 IAPP project.

• International and national Master/PhD theses supervision, and teaching at graduate and doctorate courses at 6 different Universities in Europe.

• 23 scientific awards, distinctions and fellowships.

Highlighted publications

  1. Molina NM….Altmäe S. New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? Biomolecules 2020 Apr 11;10(4). pii E593
  2. Altmäe S et al. The seminal microbiome in health and disease. Nature Reviews Urology 2019 Dec;16(12):703-721 (IF 9.3, Nature Publishing Group)
  3. Altmäe S, Mendoza-Tesarik R, Mendoza C, Mendoza N, Cucinelli F, Tesarik J. Effect of Growth Hormone on Uterine Receptivity in Women With Repeated Implantation Failure in an Oocyte Donation Program: A Randomized Controlled Trial. J Endocr Soc. 2017 Dec 19;2(1):96-105. doi: 10.1210/js.2017-00359. eCollection 2018 Jan 1. Erratum in: J Endocr Soc. 2018 Jan 08;2(2):133. 
  4. Altmäe S et al. Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. Scientific Reports 2017 Aug;7(1):10077. (IF 4.3, Nature Publishing Group). Cited 8 times.
  5. Altmäe S, Segura MT, Esteban FJ, Bartel S, Brandi P, Irmler M, Beckers J, Demmelmair H, López-Sabater C, Koletzko B, Krauss-Etschmann S, Campoy C. Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome. PLoS One. 2017 Jan 26;12(1):e0169223. doi: 10.1371/journal.pone.0169223. eCollection 2017.
  6. Altmäe S, Tamm-Rosenstein K, Esteban FJ, Simm J, Kolberg L, Peterson H, Metsis M, Haldre K, Horcajadas JA, Salumets A, Stavreus-Evers A. Endometrial transcriptome analysis indicates superiority of natural over artificial cycles in recurrent implantation failure patients undergoing frozen embryo transfer. Reprod Biomed Online. 2016 Jun;32(6):597-613. doi: 10.1016/j.rbmo.2016.03.004. Epub 2016 Mar 28.
  7. Altmäe S et al. Guidelines for the design, analysis and interpretation of ‘omics’ data: focus on human endometrium. Hum Reprod Update 2014 Jan-Febr;(20)1:12-28. (IF 11.7, The best journal in Obsterics/Gynecology and Reproductive Biology categories, Q1) Cited 44 times.
  8. Altmäe S et al. Genetic predictors of controlled ovarian hyperstimulation: where do we stand today? Hum Reprod Update 2011 Nov-Dec;17(6):813-828. (IF 11.7, The best journal in Obsterics/Gynecology and Reproductive Biology categories, Q1) Cited 53 times.
  9. Altmäe S et al. Research Resource: Interactome of human embryo implantation: identification of gene expression pathways, regulation, and integrated regulatory networks. Mol Endocrinol 2012 Jan;26(1):203-217. (IF 3.9, Q2 in Endocrinology and Metabolism, 37/138) Cited 44 times.
  10. Altmäe S et al. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod. 2010 Mar;16(3):178-87. (IF 3.6, Q1 Obsterics/Gynecology, 10/80, and Reproductive Biology, 4/29, categories) Cited 71 times.

Todas sus publicaciones en UCEENS

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Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UG

Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UGR