Publicación

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Carbohydrates, Active Lipids and Nitrogen Compounds

  • ANNALS OF NUTRITION AND METABOLISM
  • Autores
    Pastor-Villaescusa, B; Rangel-Huerta, OD; Aguilera, CM; Gil, A
  • Año Publicación
    2015
  • Volumen
    66
  • Número
    2-Mar
  • Pág. Inicio
    168
  • Pág. Fin
    181
  • Pág. Fin
    168
Referencia Citadas
63
Citas Web of Science
6
Total de veces citado (Z9)
7
Recuento Uso 180 días
1
Recuento Uso 5 años
19

Background/Aims: The prevalence of cardiovascular diseases (CVD) is rising and it is the prime cause of death in all developed countries. Bioactive compounds (BACs) can play a role in CVD prevention and treatment. To examine the scientific evidence supporting BACs groups’ efficacy in CVD prevention and treatment, we conducted a systematized review. Methods: All available information on Medline, LILACS and EMBASE; all randomized controlled trials (RCTs) with prospective, parallel or crossover designs in humans in which the BACs effect was compared with that of placebo/control. Vascular homeostasis, blood pressure, endothelial function, oxidative stress and inflammatory biomarkers were considered primary outcomes. Results: We selected 26 articles, verifying their quality based on the Scottish Intercollegiate Guidelines Network, establishing diverse quality levels of scientific evidence according to the design and bias risk of a study. Grades of recommendation were included, depending on the evidence strength of antecedents. Conclusions: Evidence shows that certain BACs’ derivative from active lipids and nitrogen compounds, mainly from horse chestnut seed extract, sterol plants, allium derivatives, and certain doses of beta-glucans, can be helpful in decreasing the prevalence of CVD risk factors. However, further rigorous evidence is necessary to support and prove BACs’ effect on CVD prevention and treatment. (C) 2015 S. Karger AG, Basel


Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UG

Web financiada por la Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, Fondo Europeo de Desarrollo Regional (FEDER), proyecto SOMM17/6107/UGR